Demodectic mange in domestic dogs is an inflammatory skin disease caused by tiny mites of the Demodex canis species. It is also called demodicosis, demodex, red mange or follicular mange. These mites are too small to be seen with the naked eye. They normally are present in very small numbers in the hair follicles and sebaceous glands of healthy dogs. Sebaceous glands are those that secrete a substance called “sebum,” which is the oily secretion coming from sebaceous gland ducts that open into the hair follicles. Sebum is made of fat and skin debris and functions to lubricate and moisturize the skin. Demodectic mange develops when the affected dog’s immune system is suppressed, weakened or otherwise compromised such that it cannot keep the rise of these mites at bay.