Feline Stomatitis Study

The Dentistry Service of the University of Pennsylvania Veterinary Hospital is currently recruiting cats with oral stomatitis for a pilot study to evaluate the effectiveness of a new drug when injected into oral lesions. Knowledge gained from this study may provide an advancement in the treatment of feline stomatitis, and possibly similar conditions seen in humans. We are seeking ten cats with bilateral caudal stomatitis to be enrolled as a pilot to evaluate the potential for future studies.

Feline stomatitis is a poorly understood inflammatory disease of the oral mucosal linings which causes pain and suffering in domestic cats. Symptoms of oral pain include decreased appetite, vocalizing when eating, yawning or opening the mouth, and drooling. Severe chronic inflammation is seen in the gums and adjacent soft tissues around the teeth and in the back of the mouth, making it difficult to chew and swallow. Full-mouth extraction is currently the treatment of choice, which does provide significant benefit in approximately 80% of affected cats. However, approximately 20% of cats that underwent surgical extractions have continued inflammation and pain.

Eligibility
Criteria Include:

Cats
must be deemed to be otherwise healthy based on physical
examination and blood work.

Cats
must be previously diagnosed with bilateral caudal mucositis which has been unresponsive to other treatments, including full-mouth (or nearly full-mouth)
extractions.

Enrollment will finish May 15, 2012 or when 10 cats have been enrolled.


If
you are interested in enrolling a patient for this study, or would like more information, please contact the Veterinary Clinical Investigations Center at 215-573-0302 or vcic@vet.upenn.edu

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