Von Willebrand Disease in Dogs | Causes & Prevention
PetWave | Dog & Cat Information

Causes and Prevention of Von Willebrand Disease in Dogs

Causes of von Willebrand Disease in Dogs

Von Willebrand disease is caused by genetic mutations that impair the synthesis, release, function or stability of von Willebrand factor. Males and females express and transmit these genetic mutations to their offspring with equal frequency. The severity of disease depends upon the degree to which the genetic mutations are expressed.

There are three recognized classifications of vWD, and affected breeds tend to fall into one of those three categories. Type 1 vWD is a quantitative reduction in the amount of circulating vWF and typically causes mild to moderate symptoms. It is the most common form of the disease and affects many breeds. Type 2 vWD is both a quantitative and a functional defect in vWF that causes severe signs, primarily in German Wireharied and Shorthaired Pointers. Type 3 vWD also causes severe disease; it predominates in Chesapeake Bay Retrievers, Dutch Kooikers, Scottish Terriers, Shetland Sheepdogs and occasionally other breeds. Type 3 vWD is a complete absence of detectable vWF in the affected dog’s blood.

Preventing von Willebrand Disease

Because of the strong genetic component, the only realistic way to prevent von Willebrand disease is to remove clinically affected animals from the breeding population. Dogs in predisposed breeds can be screened to ascertain whether they are deficient in von Willebrand factor. If they are, they should not be bred, even if they do not show symptoms of the disease.

Special Notes

Veterinarians have several fairly non-invasive ways to diagnose vWD. A DNA test is available to provide valuable information to breeders about identifying carrier and affected dogs. Most dogs with vWD have a good prognosis. With diligence and proper precautions, surgery and treatment of incidental trauma can be performed safely on dogs with this disease.

Source: PetWave


Brain, Spinal, Nerve

Dog Brain, Spinal Cord, & Nerve Disorders Center: Here you'll find in-depth information on brain,...

Retinal Detachment in Dogs

Retinal Detachment in Dogs: Learn about Retinal Detachment, including how it can affect your dog,...

Parvovirus in Dogs

Parvovirus in Dogs: Learn about Canine Parvovirus, including how it can affect your dog, and...

Hernias in Dogs

Hernias in Dogs: Learn about Hernias, including how they can affect your dog, and what...

Bloat (Gastric Dilatation and Volvulus) in Dogs

Bloat in Dogs: Learn about Gastric Dilatation and Volvulus (GDV), including how it affects your...


Dog Health Dog Health
Learn about the most common diseases affecting dogs
Puppy Training Getting a Puppy
A new puppy in the house can cause quite a whirlwind of excitement
Dog Breeds List of Dog Breeds
Comprehensive list of dog breeds with specific breed information

Find a Dog Breed?

With so many dog breeds to choose from, sometime it's easier to seach based on certain characterisitcs.

Caring for your Dog?

There is more to caring for your dog than just feeding it. Find out all you need to know to make sure your pet stays healthy.

Training your Dog?

A dog's behavior plays a key role in making a great pet. Training your dog makes a happier dog, and you will be happier too.

Ask a vet?

Have a question?
Ask a Vet Online NowSM

Ask a Vet

About Us | Review Board | Badges | Tell a Friend | Bookmark this Page | Submit Feedback | Terms of Use | Privacy Policy
Dog Breeds | Cat Breeds | Dog Health | Cat Health | Dog Training | Cat Training | Dog Care | Cat Care | Dog Adoption | Cat Food & Diet

Advertise on petwave.com - A Pet360 Media Network Partner

Become a Fan of Petwave.com on Facebook Become a Fan on Facebook Follow PetWave.com on Twitter Follow PetWave.com on Twitter Email Friend about Petwave.com Tell your friends about PetWave

© 2015 PetWave Corporation. All rights reserved
This information is not intended to replace the advice of a veterinarian. PetWave disclaims any liability for the decisions you make based on this information.
For more information view our Terms of Service.